Factors related with survival in men and women with heart failure

Abstract Funding Acknowledgements Type of funding sources: Public hospital(s). Main source(s): The study was supported by an intramural research grant from the National Institute Cardiology. Background Heart failure (HF) is a significant cause morbidity and mortality in both women men. discrepancies underlying mechanisms etiology HF sexes suggest that factors related to prognosis risk death may also be different men women. Objective aim identify with survival HF. Methods Patients hospital database coded as hospitalizations for between 01/2014 05/2019 were included analysis. In all patients, diagnosis verified. Information on HF, comorbidities, obtained available medical records. Kaplan-Meier curves generated analyze time-to-event data compare Multivariable Cox proportional hazard analysis used evaluate factors. Results 1824 (70.1%) 777 (29.9%) included. Women older than (68.3 vs. 62.4 years; p<0.001). median follow-up time (2.43 2.42 p=0.550), proportion deaths during similar (37.8 34.5%; p=0.112). sex alike (p=0.2732) are presented Figure 1. results multivariable hazards Table respectively, after adjustment other covariates, association increased documented for: catecholamines (HR=2.27 HR=2.92), tricuspid regurgitation (HR=1.46 HR=1.66), renal (HR=1.59 HR=1.68), liver (HR=1.90 HR=2.44), anemia (HR=1.51 HR=1.46) emergency admission (HR=1.21 HR=1.77). optimal dose ACEI associated decreased (HR=0.75 HR=0.60 women). men, we found factors, such diuretics (HR=2.29), chronic (HR=1.87), ischemic (HR=1.40), atherosclerosis (HR=1.37), stroke (HR = 1.28), cardioverter defibrillator implantation (HR=1.27), ventricular arrythmias (HR=1.24), age (HR=1.02) higher death. Furthermore, only dementia (HR=2.26), hypertension (HR=1.81), amiodarone (HR=1.68), aortic stenosis (HR=1.52), myocardial infarction (HR=1.46), while lower increasing number comorbidities (HR=0.86). Conclusions Overall similar, well strength direction relationship common However, some predictors differed women, which should draw our attention potential differences gender-related parameters affecting